T cells sense biophysical cues using lamellipodia and filopodia to optimize intraluminal path finding
نویسندگان
چکیده
منابع مشابه
Novel Roles of Formin mDia2 in Lamellipodia and Filopodia Formation in Motile Cells
Actin polymerization-driven protrusion of the leading edge is a key element of cell motility. The important actin nucleators formins and the Arp2/3 complex are believed to have nonoverlapping functions in inducing actin filament bundles in filopodia and dendritic networks in lamellipodia, respectively. We tested this idea by investigating the role of mDia2 formin in leading-edge protrusion by l...
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Src tyrosine kinases have been implicated in axonal growth and guidance; however, the underlying cellular mechanisms are not well understood. Specifically, it is unclear which aspects of actin organization and dynamics are regulated by Src in neuronal growth cones. Here, we investigated the function of Src2 and one of its substrates, cortactin, in lamellipodia and filopodia of Aplysia growth co...
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ژورنال
عنوان ژورنال: Integrative Biology
سال: 2014
ISSN: 1757-9694,1757-9708
DOI: 10.1039/c4ib00021h